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Introduction
1. Cardiopulmonary system
2. Pulmonary system
3. Neuromuscular system
3.1 Central nervous system
3.2 Anatomy and function of spinal cord
3.3 Peripheral nervous system
3.4 Differential diagnosis of central nervous system pathologies
3.5 Differential diagnosis of peripheral nervous system
3.6 Other neurological conditions
3.7 Interventions for neurological conditions
3.8 Vestibular system
4. Pediatrics
5. Musculoskeletal system
6. Other system
7. Non-systems
Wrapping up
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3.1 Central nervous system
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3. Neuromuscular system

Central nervous system

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Upper motor neuron units

Definitions
Upper motor neuron units
Network of neurons in which cell bodies originate in the cerebral cortex (brain), brainstem, and spinal cord. Characteristics of disease processes that are upper motor units are weakness, hyperreflexia, and hypertonia.

Anatomy of brain

  • Brain is divided into two (2) hemispheres divided externally by longitudinal fissure and internally by corpus callosum
    • Right hemisphere:
      • Spatial awareness
      • Emotional processing
      • Facial recognition
      • Creativity
      • Abstract thought
      • Controls left side of body
    • Left hemisphere
      • Language
      • Logic and reasoning
      • Analytical thinking
      • Controls right side of body

Image #15

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https://open.oregonstate.education/aandp/chapter/14-3-the-brain-and-spinal-cord/

  • Brain is divided into six (6) lobes with distinct characteristics which work collectively to assist functional:
    • Frontal lobe:
      • Executive function
      • Voluntary movement
      • Problem solving
      • Learning
      • Behavior
      • Impulse control
      • Personality
      • Social behavior
      • Expressive language (Broca’s area)
    • Parietal lobe:
      • Awareness of somatic sense- touch, pain, temperature, pressure, vibration
      • Processing somatic sensation- analyzing, recognizing, and development of memory of somatic sense
      • Spatial and body awareness
      • Coordination of visual, auditory, and somatosensory stimuli
    • Temporal lobe:
      • Hearing
      • Receptive language (Wernicke’s area)
      • Memory
        • Declarative: memory regarding names of person, places, or things
        • Procedural: memory of how to perform activities such as brushing teeth, putting on making-up, etc
    • Occipital lobe:
      • Awareness of visual stimuli
      • Processing of visual stimuli
    • Cerebellum:
      • Motor learning
      • Coordinate movement
      • Balance and equilibrium
      • Proprioception sense
      • Maintain posture
    • Brainstem:
      • Ascending and descending tracts are located in brainstem
      • Heart rate and respiration rate
      • Sleep and wake cycles
      • Digestion
      • Body temperature
      • Vomiting
      • Swallowing

Image #16

alt_text

https://open.oregonstate.education/aandp/chapter/14-3-the-brain-and-spinal-cord/

Image #17

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https://open.oregonstate.education/aandp/chapter/14-3-the-brain-and-spinal-cord/

Other Important Brain Structures

  • Thalamus
    • Receives sensory information from the body
    • Sends motor information to the body
    • Assists with memory processing
  • Hypothalamus
    • Maintains homeostasis within the body by regulation of hormones
  • Basal ganglia
    • Initiation of movements
    • Assists with maintaining posture and muscle tone
    • Assists with controlling voluntary movements

Arterial Circulation of Brain

Image #20

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https://upload.wikimedia.org/wikipedia/commons/4/4a/Cerebral_vascular_territories.jpg

Circle of Willis

  • Network of arteries that provide blood supply to the brain
  • Major arteries
    • Anterior cerebral artery (ACA)
      • Supplies frontal, pre-frontal, and supplementary motor cortex as well as circulation to primary motor and sensory cortex
      • Injury to the ACA can cause hemiparesis with weakness of lower extremity > upper extremity with sparing of face, apraxia, abulia, akinetic mutism, urinary incontience
    • Anterior communicating artery
      • Blood supply that connect the left and right ACA
      • Injury to anterior communicating artery can cause visual disturbances, memory deficits, cognitive impairment, severe headache, altered mental status, and impaired executive function
    • Middle cerebral artery
      • Blood supply to the frontal, temporal, parietal, and deeper structures
      • Injury to the middle cerebral artery can cause hemiparesis with weakness of upper extremity >lower extremity; innervates both Broca’s area and Wernicke’s area, neglect
    • Internal carotid artery
      • Provides oxygenation to the brain
      • Injury can lead to blurred vision, confusion, memory loss, hemiparesis, or sudden death
    • Posterior cerebral artery
      • Supplies blood to occipital and temporal lobes
      • Injury can cause visual field loss, visual impairment, headache, confusion, and memory impairments
    • Posterior communicating artery
      • Connects the internal carotid artery to the posterior cerebral artery
      • Injury can cause vi field loss, ptosis, diplopia, headache, confusion, memory impairment, hemiparesis

Other Important arteries of brain

  • Basilar artery
    • Supplies: Brainstem, occipital lobe, cerebellum, thalamus, medial temporal lobes
    • Functions: Supports autonomic regulation
    • Injury Signs: Hemiparesis or quadriparesis, facial paralysis, dizziness, headache, dysarthria
    • Involvement: Combines with vertebral artery → vertebrobasilar system → damage to both can cause locked-in syndrome
  • Vertebral artery
    • Supplies: Brain and spinal cord
    • Injury Signs: Headache, neck pain, dysarthria, dysphagia, seizures, impaired coordination, sensory/motor deficits to face and body
    • Involvement: Joins basilar artery → vertebrobasilar system → dual injury may result in locked-in syndrome
  • Posterior inferior cerebellar communicating artery (PICA, Wallenburg syndrome, or Lateral medullary syndrome)
    • Supplies blood flow to the medulla, fourth ventricle, and cerebellum
    • Injury can cause diplopia, ptosis, facial pain, vertigo, slurred speech, hoarseness, balance deficits, sensory deficits on same side face and contralateral body
Definitions
Locked-in syndrome
Paralysis of all voluntary muscles with the exception of eye movement remains intact. The individual remains conscious but is unable to speak or move.

Image 18

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https://open.oregonstate.education/app/uploads/sites/157/2019/07/1314_Circle_of_WillisN.jpg

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