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Introduction
1. Medications
2. Patient safety and quality assurance
3. Order entry and processing
3.1 Procedures to compound non-sterile products
3.2 Formulas and calculations
3.3 Medical terminology and sig codes
3.4 Prescription intake and order entry
3.5 Additional information
3.6 Roles and responsibilities of the pharmacy technician
3.7 Health insurance plans and common terms
3.8 Inventory management
4. Federal requirements
Wrapping up
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3.3 Medical terminology and sig codes
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3. Order entry and processing
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Medical terminology and sig codes

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Sig codes are standard prescription abbreviations commonly used in pharmacies and by healthcare providers. The term Sig comes from the Latin word Signetur, meaning “let it be labeled.”

Most Sig codes tell you:

  • how to use a medication
  • how much to use
  • when to use it
  • how often to use it

Sig codes may be written in uppercase or lowercase, as long as the letters are used correctly. Because these are standard codes, they help prescriptions get processed and filled more quickly. However, errors can happen if someone isn’t trained to interpret the abbreviations or if a handwritten prescription is hard to read.

Table showing Sig codes denoting how often to take a medication

Sig code Meaning
prn As needed
STAT Immediately
2STAT Take 2 (tablets, capsules, etc.) immediately
q Every
qd Once a day or every day
qh Every hour
q4h Every 4 hours
bid Twice daily
tid Three times a day
qid Four times a day
qod Every other day
1XD One time a day
AM In the morning
PM In the evening
qAM Every morning
AMPM In the morning and evening
hs At bedtime
ASAP As soon as possible
c With
UD As directed
QS Quantity sufficient

Table showing Sig codes denoting routes to take a medication

Sig code Route
ad In right ear
as In left ear
au In both ears
od In right eye
os In left eye
ou In both eyes
po By mouth
PR Per rectal
im Intramuscularly
pv Per vaginally
sl Sublingual
en In each nostril

Table showing other common abbreviations

Abbreviation Meaning
gtt(s) Drop(s)
tab Tablet
supp Suppository
SS One-half
S/S Swish and swallow
pc After meals
mg Milligram
ml Milliliter
tbsp Tablespoon (15 ml)
tsp Teaspoon (5ml)
cap Capsule
INH Inhale
INJ Inject
SR Sustained release
XR Extended-release
NPI National provider identifier

Examples of how to use the Sig codes and abbreviations

  1. 1 tab po daily - take one tablet by mouth daily.

  2. 1 tsp po TID - take one teaspoon by mouth three times a day.

  3. 1 tbsp po q6h - take one tablespoon by mouth every six hours.

  4. 1-2 gtts qd ad - instill 1-2 drops daily in the right ear.

  5. 1 tab pr qd prn - insert one tablet rectally daily as needed.

Sig codes overview

  • Standard prescription abbreviations for medication instructions
  • Indicate usage, dosage, timing, and frequency
  • Errors possible if misinterpreted or illegible

Frequency sig codes

  • prn: as needed
  • STAT: immediately; 2STAT: take 2 immediately
  • q: every (e.g., q4h: every 4 hours)
  • qd/1XD: once a day; qh: every hour; qod: every other day
  • bid: twice daily; tid: three times a day; qid: four times a day
  • AM/PM: morning/evening; qAM: every morning; AMPM: morning and evening
  • hs: at bedtime; ASAP: as soon as possible
  • c: with; UD: as directed; QS: quantity sufficient

Route sig codes

  • ad/as/au: in right/left/both ears
  • od/os/ou: in right/left/both eyes
  • po: by mouth; PR: per rectal; pv: per vaginally
  • im: intramuscularly; sl: sublingual; en: in each nostril

Other common abbreviations

  • gtt(s): drop(s); tab: tablet; cap: capsule; supp: suppository
  • SS: one-half; S/S: swish and swallow; pc: after meals
  • mg: milligram; ml: milliliter
  • tbsp: tablespoon (15 ml); tsp: teaspoon (5 ml)
  • INH: inhale; INJ: inject
  • SR: sustained release; XR: extended-release
  • NPI: national provider identifier

Sig code usage examples

  • 1 tab po daily: one tablet by mouth daily
  • 1 tsp po TID: one teaspoon by mouth three times a day
  • 1 tbsp po q6h: one tablespoon by mouth every six hours
  • 1-2 gtts qd ad: 1-2 drops daily in right ear
  • 1 tab pr qd prn: one tablet rectally daily as needed

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Medical terminology and sig codes

Sig codes are standard prescription abbreviations commonly used in pharmacies and by healthcare providers. The term Sig comes from the Latin word Signetur, meaning “let it be labeled.”

Most Sig codes tell you:

  • how to use a medication
  • how much to use
  • when to use it
  • how often to use it

Sig codes may be written in uppercase or lowercase, as long as the letters are used correctly. Because these are standard codes, they help prescriptions get processed and filled more quickly. However, errors can happen if someone isn’t trained to interpret the abbreviations or if a handwritten prescription is hard to read.

Table showing Sig codes denoting how often to take a medication

Sig code Meaning
prn As needed
STAT Immediately
2STAT Take 2 (tablets, capsules, etc.) immediately
q Every
qd Once a day or every day
qh Every hour
q4h Every 4 hours
bid Twice daily
tid Three times a day
qid Four times a day
qod Every other day
1XD One time a day
AM In the morning
PM In the evening
qAM Every morning
AMPM In the morning and evening
hs At bedtime
ASAP As soon as possible
c With
UD As directed
QS Quantity sufficient

Table showing Sig codes denoting routes to take a medication

Sig code Route
ad In right ear
as In left ear
au In both ears
od In right eye
os In left eye
ou In both eyes
po By mouth
PR Per rectal
im Intramuscularly
pv Per vaginally
sl Sublingual
en In each nostril

Table showing other common abbreviations

Abbreviation Meaning
gtt(s) Drop(s)
tab Tablet
supp Suppository
SS One-half
S/S Swish and swallow
pc After meals
mg Milligram
ml Milliliter
tbsp Tablespoon (15 ml)
tsp Teaspoon (5ml)
cap Capsule
INH Inhale
INJ Inject
SR Sustained release
XR Extended-release
NPI National provider identifier

Examples of how to use the Sig codes and abbreviations

  1. 1 tab po daily - take one tablet by mouth daily.

  2. 1 tsp po TID - take one teaspoon by mouth three times a day.

  3. 1 tbsp po q6h - take one tablespoon by mouth every six hours.

  4. 1-2 gtts qd ad - instill 1-2 drops daily in the right ear.

  5. 1 tab pr qd prn - insert one tablet rectally daily as needed.

Key points

Sig codes overview

  • Standard prescription abbreviations for medication instructions
  • Indicate usage, dosage, timing, and frequency
  • Errors possible if misinterpreted or illegible

Frequency sig codes

  • prn: as needed
  • STAT: immediately; 2STAT: take 2 immediately
  • q: every (e.g., q4h: every 4 hours)
  • qd/1XD: once a day; qh: every hour; qod: every other day
  • bid: twice daily; tid: three times a day; qid: four times a day
  • AM/PM: morning/evening; qAM: every morning; AMPM: morning and evening
  • hs: at bedtime; ASAP: as soon as possible
  • c: with; UD: as directed; QS: quantity sufficient

Route sig codes

  • ad/as/au: in right/left/both ears
  • od/os/ou: in right/left/both eyes
  • po: by mouth; PR: per rectal; pv: per vaginally
  • im: intramuscularly; sl: sublingual; en: in each nostril

Other common abbreviations

  • gtt(s): drop(s); tab: tablet; cap: capsule; supp: suppository
  • SS: one-half; S/S: swish and swallow; pc: after meals
  • mg: milligram; ml: milliliter
  • tbsp: tablespoon (15 ml); tsp: teaspoon (5 ml)
  • INH: inhale; INJ: inject
  • SR: sustained release; XR: extended-release
  • NPI: national provider identifier

Sig code usage examples

  • 1 tab po daily: one tablet by mouth daily
  • 1 tsp po TID: one teaspoon by mouth three times a day
  • 1 tbsp po q6h: one tablespoon by mouth every six hours
  • 1-2 gtts qd ad: 1-2 drops daily in right ear
  • 1 tab pr qd prn: one tablet rectally daily as needed