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Introduction
1. Cardiopulmonary system
2. Pulmonary system
3. Neuromuscular system
4. Pediatrics
5. Musculoskeletal system
6. Other system
6.1 Integumentary system
6.2 Lymphedema
6.3 Gastrointestinal and reproductive systems
6.4 Urinary incontinence and renal disorders
6.5 Endocrine and metabolic systems
6.6 Cancer and psychological conditions
6.7 Infectious disease, immune disorders, and hematological disorders
7. Non systems
Wrapping up
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6.3 Gastrointestinal and reproductive systems
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6. Other system
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Gastrointestinal and reproductive systems

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PTA role reminder: Across every system in this chapter, the PTA’s job is to carry out the plan of care the supervising PT has already established - not to diagnose a condition or change the plan. That means monitoring for the signs and adverse responses described below, collecting objective data, and reporting significant changes to the PT rather than modifying the intervention yourself.

Common gastrointestinal tests

Gastroesophageal reflux disease (GERD)

  • Description: Backflow of stomach acid into the esophagus due to a weakened lower esophageal sphincter
  • Symptoms: Heartburn, regurgitation, chest pain, difficulty swallowing
  • PT implications: Avoid exercises that increase intra-abdominal pressure; encourage upright positions after eating

Peptic ulcer disease (PUD)

  • Description: Open sores in the stomach or duodenal lining, often caused by H. pylori infection or NSAIDs
  • Symptoms: Epigastric pain, nausea, bloating, bloody stool (if severe)
  • PT implications: Monitor for signs of GI bleeding (dark stool, fatigue, pallor)

Irritable bowel syndrome (IBS)

  • Description: Functional GI disorder with chronic abdominal pain and altered bowel habits (diarrhea, constipation, or both)
  • Symptoms: Cramping, bloating, diarrhea, constipation, mucus in stool
  • PT implications: Stress management, exercise to regulate bowel motility

Crohn’s disease

  • Description: Chronic inflammation of any part of the GI tract, often the small intestine
  • Symptoms: Abdominal pain, diarrhea, weight loss, fatigue, malnutrition
  • PT implications: Address fatigue, joint pain, and osteoporosis risks due to long-term steroid usage for disease management.

Ulcerative colitis

  • Description: Chronic inflammation and ulcers in the colon and rectum
  • Symptoms: Bloody diarrhea, urgency, abdominal cramping, weight loss
  • PT implications: Monitor for dehydration, anemia, and musculoskeletal complications

Diverticulitis

  • Description: Infection or inflammation of diverticula (pouches in the colon wall)
  • Symptoms: Lower left quadrant pain, fever, nausea, bowel habit changes
  • PT implications: Avoid increased intra-abdominal pressure (e.g., Valsalva maneuver)

Celiac disease

  • Description: Autoimmune disorder triggered by gluten, leading to villous atrophy in the small intestine
  • Symptoms: Malabsorption, diarrhea, bloating, fatigue, weight loss
  • PT implications: Monitor for signs of malnutrition, osteoporosis, and neurological symptoms (tingling, numbness)

Hepatitis (A, B, C, D, E)

  • Description: Inflammation of the liver, often viral
  • Symptoms: Jaundice, fatigue, dark urine, nausea, right upper quadrant pain
  • PT implications: Energy conservation techniques, avoid strenuous exercise during active infection

Cirrhosis

  • Description: Chronic liver disease with fibrosis and impaired liver function
  • Symptoms: Jaundice, ascites, hepatomegaly, fatigue, confusion (hepatic encephalopathy)
  • PT implications: Watch for bruising, bleeding, and fall risk due to balance deficits

Pancreatitis

  • Description: Inflammation of the pancreas, often due to gallstones or alcohol abuse
  • Symptoms: Severe epigastric pain radiating to the back, nausea, vomiting
  • PT implications: Monitor for signs of multi-organ failure, avoid activities that increase abdominal pressure

When to stop and notify the PT: New or worsening abdominal pain or signs of GI bleeding (dark or bloody stool, unexplained fatigue, pallor) are reasons to stop the current activity and notify the supervising PT - not signs to work through.

Key referred pain sites

Key clinical patterns

  • Peptic ulcers → Epigastric pain that may radiate to the back
  • Pancreatitis → Pain in the mid-back and left shoulder
  • Gallbladder issues (cholecystitis, gallstones) → Right shoulder, right upper quadrant pain, worsens after fatty meals
  • Appendicitis → Periumbilical pain progressing to the right lower quadrant (McBurney’s point)
  • Hepatic (liver) issues → Right upper quadrant pain, right shoulder pain, jaundice may be present
  • Esophagus → mid chest, mid-back
  • Stomach → epigastric region, left upper quadrant, mid-back
  • Small intestine → periumbilical region
  • Large intestine → lower abdomen, sacral region
  • Rectum → sacral region, perineum
Referred pain sites
Referred pain sites
By - OpenStax College, Autonomic Reflexes and Homeostasis http://cnx.org/content/m46579/1.2/, CC-BY 3.0
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Wikimedia Commons
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CC BY 3.0

Reproductive system

Male reproductive system

Anatomy and physiology

  • Primary structures: Testes, epididymis, vas deferens, seminal vesicles, prostate gland, urethra, and penis
  • Function: Produces sperm and male sex hormones (testosterone)
  • Hormonal regulation:
    • Hypothalamus → Gonadotropin-releasing hormone (GnRH)
    • Pituitary → Luteinizing hormone (LH) & Follicle-stimulating hormone (FSH)
      • LH stimulates testosterone production in the testes.
      • FSH supports spermatogenesis
Definitions
Testosterone
Steroid hormone that drives male secondary sexual characteristics. It’s produced mainly by the testes (Leydig cells) in males, and in smaller amounts by the ovaries and adrenal cortex in females.
Gonadotropin-releasing hormone
Hormone produced in the hypothalamus that stimulates the pituitary gland to release follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which in turn regulate the function of the gonads (testes and ovaries).
Luteinizing hormone
Hormone secreted by the anterior pituitary; in males it stimulates testosterone production in the testes, and in females it triggers ovulation and stimulates estrogen and progesterone production.
Follicle-stimulating hormone
Stimulates egg production in females, regulates the menstrual cycle, and supports sperm production in males.

Common male reproductive disorders

Benign prostatic hyperplasia (BPH)

  • Non-cancerous enlargement of the prostate
  • Symptoms: Urinary frequency, nocturia, weak stream, incomplete bladder emptying
  • Treatment: Medications (alpha-blockers), surgery if severe

Prostatitis

  • Inflammation of the prostate, often bacterial
  • Symptoms: Painful urination, pelvic pain, flu-like symptoms
  • Treatment: Antibiotics, anti-inflammatories

Prostate cancer

  • Most common cancer in men
  • Symptoms: Often asymptomatic early, later include urinary dysfunction and bone pain (metastasis)
  • Treatment: Surgery, radiation, hormone therapy

Erectile dysfunction

  • Inability to achieve/maintain an erection
  • Causes: Vascular disease, diabetes, psychological factors
  • Treatment: Medications, lifestyle modifications

Testicular cancer

  • Most common in men 15-35 years
  • Symptoms: Painless testicular lump, swelling
  • Treatment: Surgery (orchiectomy), chemotherapy, radiation

Female reproductive system

Anatomy and physiology

  • Primary structures: Ovaries, fallopian tubes, uterus, cervix, vagina, external genitalia
  • Function: Produces eggs, sex hormones (estrogen, progesterone), and supports fetal development during pregnancy
  • Hormonal regulation:
    • Hypothalamus → Gonadotropin-releasing hormone (GnRH)
    • Pituitary → Luteinizing hormone (LH) & Follicle-stimulating hormone (FSH)
      • LH regulates the menstrual cycle, triggers ovulation, and stimulates the ovaries to produce essential steroid hormones like estrogen and progesterone.
      • FSH stimulates the ovaries to grow follicles and mature eggs each month.
Definitions
Estrogen
Any of a group of steroid hormones that promote the development and maintenance of female characteristics of the body.
Progesterone
Steroid hormone released by the corpus luteum that stimulates the uterus to prepare for pregnancy.

Common female reproductive disorders

Polycystic ovarian syndrome (PCOS)

  • Hormonal disorder causing irregular ovulation, excess androgens, and ovarian cysts
  • Symptoms: Irregular periods, infertility, insulin resistance, and hirsutism, a condition characterized by excessive hair growth in women in a male-pattern distribution.
  • Treatment: Hormonal therapy, weight management, insulin sensitizers

Endometriosis

  • Growth of endometrial tissue outside the uterus
  • Symptoms: Pelvic pain, dysmenorrhea, infertility
  • Treatment: Pain management, hormonal therapy, surgery

Uterine fibroids

  • Non-cancerous tumors of the uterus
  • Symptoms: Heavy menstrual bleeding, pelvic pain, infertility
  • Treatment: Hormonal therapy, surgery (hysterectomy, myomectomy)

Pelvic inflammatory disease (PID)

  • Infection of the female reproductive organs (often due to sexually transmitted diseases)
  • Symptoms: Pelvic pain, fever, abnormal vaginal discharge
  • Treatment: Antibiotics, hospitalization if severe

Ovarian cancer

  • Often detected late because early symptoms are vague and nonspecific
  • Symptoms: Abdominal bloating, pelvic pain, urinary urgency
  • Treatment: Surgery, chemotherapy

Breast cancer

  • Most common cancer in women
  • Risk factors: Family history, hormone exposure
  • Symptoms: Lump, nipple changes, skin dimpling
  • Treatment: Surgery, chemotherapy, radiation, hormone therapy

Pregnancy considerations for physical therapy

Physiological changes during pregnancy

Musculoskeletal changes

  • Increased lumbar lordosis and anterior pelvic tilt → low back pain
  • Increased ligamentous laxity due to Relaxin hormone → joint instability, risk of injury
  • Widening of the pelvis → sacroiliac (SI) joint pain, pubic symphysis dysfunction
  • Diastasis recti (separation of the rectus abdominis)
Definitions
Relaxin hormone
Hormone, primarily associated with pregnancy, that loosens ligaments and softens the cervix, preparing the body for childbirth.

Cardiovascular changes

  • Increased blood volume (40-50%) and heart rate
  • Decreased blood pressure in the first and second trimesters (due to vasodilation)
  • Risk of supine hypotensive syndrome (compression of the inferior vena cava)

Respiratory changes

  • Increased oxygen consumption
  • Decreased lung expansion due to elevated diaphragm → shortness of breath

Metabolic changes

  • Increased caloric demands.
  • Gestational diabetes risk due to insulin resistance.

Other changes

  • Increased urinary frequency due to bladder compression
  • Weight gain (25-35 lbs is the normal range)
  • Hormonal changes (progesterone, estrogen, relaxin) affect mood, joints, and metabolism
  • De Quervain’s and carpal tunnel syndrome can both occur during pregnancy due to hormonal changes and fluid retention, which increase pressure on the nerves and tendons in the wrist.

Safe exercise guidelines for pregnancy

  • Mode: Walking, swimming, cycling, low-impact aerobics.
  • Intensity: Moderate (should be able to talk while exercising)
  • Duration: 150 minutes per week (30 min/day, most days)
  • Avoid:
    • Supine exercises after 20 weeks (risk of supine hypotensive syndrome)
    • Overheating (hot yoga, saunas).
    • Valsalva maneuver (holding breath during exertion)
    • High-impact or contact sports

Contraindications to exercise during pregnancy

  • Absolute:
    • Incompetent cervix
    • Placenta previa (after 26 weeks)
    • Preeclampsia
    • Multiple gestation with risk of preterm labor
    • Ruptured membranes
    • Persistent vaginal bleeding
    • Preterm labor
  • Relative:
    • Severe anemia
    • Unevaluated maternal cardiac disease
    • Chronic bronchitis
    • Poorly controlled diabetes or hypertension

Postpartum considerations

  • Pelvic floor dysfunction
    • Interventions: Kegels, biofeedback, bladder retraining
  • Postural syndromes
    • Due to breastfeeding, baby-carrying
    • Interventions: Strengthening of the upper back, postural correction, stretching
  • Return to exercise
    • Clearance from physician (typically 6 weeks post-vaginal, 8+ weeks post-C-section)
    • Progressive return to impact activities

PTA role reminder

  • Carry out PT’s established plan of care; never diagnose or modify interventions
  • Monitor for adverse signs, collect objective data, report changes to PT

Gastroesophageal reflux disease (GERD)

  • Backflow of stomach acid from weak lower esophageal sphincter
  • Symptoms: heartburn, regurgitation, chest pain, dysphagia
  • PT: avoid increased intra-abdominal pressure exercises; upright positioning after eating

Peptic ulcer disease (PUD)

  • Open sores in stomach/duodenum from H. pylori or NSAIDs
  • Symptoms: epigastric pain, nausea, bloody stool if severe
  • PT: monitor for GI bleeding signs (dark stool, fatigue, pallor)

Irritable bowel syndrome (IBS)

  • Functional GI disorder with altered bowel habits
  • Symptoms: cramping, bloating, diarrhea/constipation
  • PT: stress management, exercise to regulate motility

Crohn’s disease

  • Chronic inflammation anywhere in GI tract (often small intestine)
  • Symptoms: abdominal pain, diarrhea, weight loss, malnutrition
  • PT: address fatigue, joint pain, steroid-related osteoporosis risk

Ulcerative colitis

  • Chronic inflammation/ulcers of colon and rectum
  • Symptoms: bloody diarrhea, urgency, cramping, weight loss
  • PT: monitor for dehydration, anemia, musculoskeletal complications

Diverticulitis

  • Infection/inflammation of colon diverticula
  • Symptoms: LLQ pain, fever, nausea, bowel changes
  • PT: avoid Valsalva/increased intra-abdominal pressure

Celiac disease

  • Autoimmune gluten reaction causing villous atrophy
  • Symptoms: malabsorption, diarrhea, bloating, fatigue
  • PT: monitor for malnutrition, osteoporosis, neuro symptoms (tingling/numbness)

Hepatitis (A-E)

  • Viral liver inflammation
  • Symptoms: jaundice, fatigue, dark urine, RUQ pain
  • PT: energy conservation; avoid strenuous exercise during active infection

Cirrhosis

  • Chronic liver disease with fibrosis
  • Symptoms: jaundice, ascites, hepatomegaly, hepatic encephalopathy
  • PT: watch for bruising/bleeding, fall risk from balance deficits

Pancreatitis

  • Pancreatic inflammation (gallstones, alcohol)
  • Symptoms: severe epigastric pain radiating to back, nausea/vomiting
  • PT: monitor for multi-organ failure signs; avoid abdominal pressure activities

When to stop and notify PT

  • New/worsening abdominal pain
  • Signs of GI bleeding (dark/bloody stool, unexplained fatigue, pallor)

Key referred pain sites

  • Peptic ulcers → epigastric, radiates to back
  • Pancreatitis → mid-back, left shoulder
  • Gallbladder → right shoulder, RUQ, worsens after fatty meals
  • Appendicitis → periumbilical → RLQ (McBurney’s point)
  • Liver → RUQ, right shoulder, jaundice
  • Esophagus → mid chest/back; Stomach → epigastric/LUQ/mid-back
  • Small intestine → periumbilical; Large intestine → lower abdomen/sacral
  • Rectum → sacral/perineum

Male reproductive system anatomy

  • Structures: testes, epididymis, vas deferens, seminal vesicles, prostate, urethra, penis
  • Function: sperm and testosterone production
  • Hormonal axis: Hypothalamus (GnRH) → Pituitary (LH, FSH)
    • LH → testosterone production
    • FSH → spermatogenesis

Male reproductive disorders

  • BPH: non-cancerous prostate enlargement; urinary frequency/nocturia/weak stream
  • Prostatitis: prostate inflammation; painful urination, pelvic pain
  • Prostate cancer: often asymptomatic early; later urinary/bone symptoms
  • Erectile dysfunction: vascular, diabetic, or psychological causes
  • Testicular cancer: common ages 15-35; painless lump/swelling

Female reproductive system anatomy

  • Structures: ovaries, fallopian tubes, uterus, cervix, vagina
  • Function: egg production, hormone production, pregnancy support
  • Hormonal axis: GnRH → LH & FSH
    • LH → ovulation, estrogen/progesterone production
    • FSH → follicle growth and egg maturation

Female reproductive disorders

  • PCOS: irregular ovulation, excess androgens, insulin resistance, hirsutism
  • Endometriosis: ectopic endometrial tissue; pelvic pain, dysmenorrhea, infertility
  • Uterine fibroids: benign tumors; heavy bleeding, pelvic pain
  • PID: reproductive organ infection; pelvic pain, fever, discharge
  • Ovarian cancer: vague early symptoms, often detected late
  • Breast cancer: most common in women; lump, nipple changes, skin dimpling

Pregnancy - musculoskeletal changes

  • Increased lumbar lordosis, anterior pelvic tilt → low back pain
  • Relaxin-induced ligamentous laxity → joint instability
  • Pelvic widening → SI joint/pubic symphysis dysfunction
  • Diastasis recti

Pregnancy - cardiovascular/respiratory changes

  • Increased blood volume (40-50%) and heart rate
  • Decreased BP in 1st/2nd trimester; supine hypotensive syndrome risk (IVC compression)
  • Increased oxygen consumption; decreased lung expansion → shortness of breath

Pregnancy - metabolic and other changes

  • Increased caloric needs; gestational diabetes risk
  • Increased urinary frequency; normal weight gain 25-35 lbs
  • Hormonal shifts affect mood/joints/metabolism
  • Risk of De Quervain’s and carpal tunnel syndrome

Safe exercise guidelines for pregnancy

  • Mode: walking, swimming, cycling, low-impact aerobics
  • Intensity: moderate (talk test); duration: 150 min/week
  • Avoid: supine exercise after 20 weeks, overheating, Valsalva, high-impact/contact sports

Contraindications to exercise during pregnancy

  • Absolute: incompetent cervix, placenta previa (>26 wks), preeclampsia, multiple gestation w/ preterm risk, ruptured membranes, persistent bleeding, preterm labor
  • Relative: severe anemia, unevaluated cardiac disease, chronic bronchitis, poorly controlled diabetes/hypertension

Postpartum considerations

  • Pelvic floor dysfunction: Kegels, biofeedback, bladder retraining
  • Postural syndromes from breastfeeding/carrying: upper back strengthening, postural correction
  • Return to exercise: physician clearance (~6 wks vaginal, 8+ wks C-section); progressive impact return

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Gastrointestinal and reproductive systems

PTA role reminder: Across every system in this chapter, the PTA’s job is to carry out the plan of care the supervising PT has already established - not to diagnose a condition or change the plan. That means monitoring for the signs and adverse responses described below, collecting objective data, and reporting significant changes to the PT rather than modifying the intervention yourself.

Common gastrointestinal tests

Gastroesophageal reflux disease (GERD)

  • Description: Backflow of stomach acid into the esophagus due to a weakened lower esophageal sphincter
  • Symptoms: Heartburn, regurgitation, chest pain, difficulty swallowing
  • PT implications: Avoid exercises that increase intra-abdominal pressure; encourage upright positions after eating

Peptic ulcer disease (PUD)

  • Description: Open sores in the stomach or duodenal lining, often caused by H. pylori infection or NSAIDs
  • Symptoms: Epigastric pain, nausea, bloating, bloody stool (if severe)
  • PT implications: Monitor for signs of GI bleeding (dark stool, fatigue, pallor)

Irritable bowel syndrome (IBS)

  • Description: Functional GI disorder with chronic abdominal pain and altered bowel habits (diarrhea, constipation, or both)
  • Symptoms: Cramping, bloating, diarrhea, constipation, mucus in stool
  • PT implications: Stress management, exercise to regulate bowel motility

Crohn’s disease

  • Description: Chronic inflammation of any part of the GI tract, often the small intestine
  • Symptoms: Abdominal pain, diarrhea, weight loss, fatigue, malnutrition
  • PT implications: Address fatigue, joint pain, and osteoporosis risks due to long-term steroid usage for disease management.

Ulcerative colitis

  • Description: Chronic inflammation and ulcers in the colon and rectum
  • Symptoms: Bloody diarrhea, urgency, abdominal cramping, weight loss
  • PT implications: Monitor for dehydration, anemia, and musculoskeletal complications

Diverticulitis

  • Description: Infection or inflammation of diverticula (pouches in the colon wall)
  • Symptoms: Lower left quadrant pain, fever, nausea, bowel habit changes
  • PT implications: Avoid increased intra-abdominal pressure (e.g., Valsalva maneuver)

Celiac disease

  • Description: Autoimmune disorder triggered by gluten, leading to villous atrophy in the small intestine
  • Symptoms: Malabsorption, diarrhea, bloating, fatigue, weight loss
  • PT implications: Monitor for signs of malnutrition, osteoporosis, and neurological symptoms (tingling, numbness)

Hepatitis (A, B, C, D, E)

  • Description: Inflammation of the liver, often viral
  • Symptoms: Jaundice, fatigue, dark urine, nausea, right upper quadrant pain
  • PT implications: Energy conservation techniques, avoid strenuous exercise during active infection

Cirrhosis

  • Description: Chronic liver disease with fibrosis and impaired liver function
  • Symptoms: Jaundice, ascites, hepatomegaly, fatigue, confusion (hepatic encephalopathy)
  • PT implications: Watch for bruising, bleeding, and fall risk due to balance deficits

Pancreatitis

  • Description: Inflammation of the pancreas, often due to gallstones or alcohol abuse
  • Symptoms: Severe epigastric pain radiating to the back, nausea, vomiting
  • PT implications: Monitor for signs of multi-organ failure, avoid activities that increase abdominal pressure

When to stop and notify the PT: New or worsening abdominal pain or signs of GI bleeding (dark or bloody stool, unexplained fatigue, pallor) are reasons to stop the current activity and notify the supervising PT - not signs to work through.

Key referred pain sites

Key clinical patterns

  • Peptic ulcers → Epigastric pain that may radiate to the back
  • Pancreatitis → Pain in the mid-back and left shoulder
  • Gallbladder issues (cholecystitis, gallstones) → Right shoulder, right upper quadrant pain, worsens after fatty meals
  • Appendicitis → Periumbilical pain progressing to the right lower quadrant (McBurney’s point)
  • Hepatic (liver) issues → Right upper quadrant pain, right shoulder pain, jaundice may be present
  • Esophagus → mid chest, mid-back
  • Stomach → epigastric region, left upper quadrant, mid-back
  • Small intestine → periumbilical region
  • Large intestine → lower abdomen, sacral region
  • Rectum → sacral region, perineum

Reproductive system

Male reproductive system

Anatomy and physiology

  • Primary structures: Testes, epididymis, vas deferens, seminal vesicles, prostate gland, urethra, and penis
  • Function: Produces sperm and male sex hormones (testosterone)
  • Hormonal regulation:
    • Hypothalamus → Gonadotropin-releasing hormone (GnRH)
    • Pituitary → Luteinizing hormone (LH) & Follicle-stimulating hormone (FSH)
      • LH stimulates testosterone production in the testes.
      • FSH supports spermatogenesis
Definitions
Testosterone
Steroid hormone that drives male secondary sexual characteristics. It’s produced mainly by the testes (Leydig cells) in males, and in smaller amounts by the ovaries and adrenal cortex in females.
Gonadotropin-releasing hormone
Hormone produced in the hypothalamus that stimulates the pituitary gland to release follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which in turn regulate the function of the gonads (testes and ovaries).
Luteinizing hormone
Hormone secreted by the anterior pituitary; in males it stimulates testosterone production in the testes, and in females it triggers ovulation and stimulates estrogen and progesterone production.
Follicle-stimulating hormone
Stimulates egg production in females, regulates the menstrual cycle, and supports sperm production in males.

Common male reproductive disorders

Benign prostatic hyperplasia (BPH)

  • Non-cancerous enlargement of the prostate
  • Symptoms: Urinary frequency, nocturia, weak stream, incomplete bladder emptying
  • Treatment: Medications (alpha-blockers), surgery if severe

Prostatitis

  • Inflammation of the prostate, often bacterial
  • Symptoms: Painful urination, pelvic pain, flu-like symptoms
  • Treatment: Antibiotics, anti-inflammatories

Prostate cancer

  • Most common cancer in men
  • Symptoms: Often asymptomatic early, later include urinary dysfunction and bone pain (metastasis)
  • Treatment: Surgery, radiation, hormone therapy

Erectile dysfunction

  • Inability to achieve/maintain an erection
  • Causes: Vascular disease, diabetes, psychological factors
  • Treatment: Medications, lifestyle modifications

Testicular cancer

  • Most common in men 15-35 years
  • Symptoms: Painless testicular lump, swelling
  • Treatment: Surgery (orchiectomy), chemotherapy, radiation

Female reproductive system

Anatomy and physiology

  • Primary structures: Ovaries, fallopian tubes, uterus, cervix, vagina, external genitalia
  • Function: Produces eggs, sex hormones (estrogen, progesterone), and supports fetal development during pregnancy
  • Hormonal regulation:
    • Hypothalamus → Gonadotropin-releasing hormone (GnRH)
    • Pituitary → Luteinizing hormone (LH) & Follicle-stimulating hormone (FSH)
      • LH regulates the menstrual cycle, triggers ovulation, and stimulates the ovaries to produce essential steroid hormones like estrogen and progesterone.
      • FSH stimulates the ovaries to grow follicles and mature eggs each month.
Definitions
Estrogen
Any of a group of steroid hormones that promote the development and maintenance of female characteristics of the body.
Progesterone
Steroid hormone released by the corpus luteum that stimulates the uterus to prepare for pregnancy.

Common female reproductive disorders

Polycystic ovarian syndrome (PCOS)

  • Hormonal disorder causing irregular ovulation, excess androgens, and ovarian cysts
  • Symptoms: Irregular periods, infertility, insulin resistance, and hirsutism, a condition characterized by excessive hair growth in women in a male-pattern distribution.
  • Treatment: Hormonal therapy, weight management, insulin sensitizers

Endometriosis

  • Growth of endometrial tissue outside the uterus
  • Symptoms: Pelvic pain, dysmenorrhea, infertility
  • Treatment: Pain management, hormonal therapy, surgery

Uterine fibroids

  • Non-cancerous tumors of the uterus
  • Symptoms: Heavy menstrual bleeding, pelvic pain, infertility
  • Treatment: Hormonal therapy, surgery (hysterectomy, myomectomy)

Pelvic inflammatory disease (PID)

  • Infection of the female reproductive organs (often due to sexually transmitted diseases)
  • Symptoms: Pelvic pain, fever, abnormal vaginal discharge
  • Treatment: Antibiotics, hospitalization if severe

Ovarian cancer

  • Often detected late because early symptoms are vague and nonspecific
  • Symptoms: Abdominal bloating, pelvic pain, urinary urgency
  • Treatment: Surgery, chemotherapy

Breast cancer

  • Most common cancer in women
  • Risk factors: Family history, hormone exposure
  • Symptoms: Lump, nipple changes, skin dimpling
  • Treatment: Surgery, chemotherapy, radiation, hormone therapy

Pregnancy considerations for physical therapy

Physiological changes during pregnancy

Musculoskeletal changes

  • Increased lumbar lordosis and anterior pelvic tilt → low back pain
  • Increased ligamentous laxity due to Relaxin hormone → joint instability, risk of injury
  • Widening of the pelvis → sacroiliac (SI) joint pain, pubic symphysis dysfunction
  • Diastasis recti (separation of the rectus abdominis)
Definitions
Relaxin hormone
Hormone, primarily associated with pregnancy, that loosens ligaments and softens the cervix, preparing the body for childbirth.

Cardiovascular changes

  • Increased blood volume (40-50%) and heart rate
  • Decreased blood pressure in the first and second trimesters (due to vasodilation)
  • Risk of supine hypotensive syndrome (compression of the inferior vena cava)

Respiratory changes

  • Increased oxygen consumption
  • Decreased lung expansion due to elevated diaphragm → shortness of breath

Metabolic changes

  • Increased caloric demands.
  • Gestational diabetes risk due to insulin resistance.

Other changes

  • Increased urinary frequency due to bladder compression
  • Weight gain (25-35 lbs is the normal range)
  • Hormonal changes (progesterone, estrogen, relaxin) affect mood, joints, and metabolism
  • De Quervain’s and carpal tunnel syndrome can both occur during pregnancy due to hormonal changes and fluid retention, which increase pressure on the nerves and tendons in the wrist.

Safe exercise guidelines for pregnancy

  • Mode: Walking, swimming, cycling, low-impact aerobics.
  • Intensity: Moderate (should be able to talk while exercising)
  • Duration: 150 minutes per week (30 min/day, most days)
  • Avoid:
    • Supine exercises after 20 weeks (risk of supine hypotensive syndrome)
    • Overheating (hot yoga, saunas).
    • Valsalva maneuver (holding breath during exertion)
    • High-impact or contact sports

Contraindications to exercise during pregnancy

  • Absolute:
    • Incompetent cervix
    • Placenta previa (after 26 weeks)
    • Preeclampsia
    • Multiple gestation with risk of preterm labor
    • Ruptured membranes
    • Persistent vaginal bleeding
    • Preterm labor
  • Relative:
    • Severe anemia
    • Unevaluated maternal cardiac disease
    • Chronic bronchitis
    • Poorly controlled diabetes or hypertension

Postpartum considerations

  • Pelvic floor dysfunction
    • Interventions: Kegels, biofeedback, bladder retraining
  • Postural syndromes
    • Due to breastfeeding, baby-carrying
    • Interventions: Strengthening of the upper back, postural correction, stretching
  • Return to exercise
    • Clearance from physician (typically 6 weeks post-vaginal, 8+ weeks post-C-section)
    • Progressive return to impact activities
Key points

PTA role reminder

  • Carry out PT’s established plan of care; never diagnose or modify interventions
  • Monitor for adverse signs, collect objective data, report changes to PT

Gastroesophageal reflux disease (GERD)

  • Backflow of stomach acid from weak lower esophageal sphincter
  • Symptoms: heartburn, regurgitation, chest pain, dysphagia
  • PT: avoid increased intra-abdominal pressure exercises; upright positioning after eating

Peptic ulcer disease (PUD)

  • Open sores in stomach/duodenum from H. pylori or NSAIDs
  • Symptoms: epigastric pain, nausea, bloody stool if severe
  • PT: monitor for GI bleeding signs (dark stool, fatigue, pallor)

Irritable bowel syndrome (IBS)

  • Functional GI disorder with altered bowel habits
  • Symptoms: cramping, bloating, diarrhea/constipation
  • PT: stress management, exercise to regulate motility

Crohn’s disease

  • Chronic inflammation anywhere in GI tract (often small intestine)
  • Symptoms: abdominal pain, diarrhea, weight loss, malnutrition
  • PT: address fatigue, joint pain, steroid-related osteoporosis risk

Ulcerative colitis

  • Chronic inflammation/ulcers of colon and rectum
  • Symptoms: bloody diarrhea, urgency, cramping, weight loss
  • PT: monitor for dehydration, anemia, musculoskeletal complications

Diverticulitis

  • Infection/inflammation of colon diverticula
  • Symptoms: LLQ pain, fever, nausea, bowel changes
  • PT: avoid Valsalva/increased intra-abdominal pressure

Celiac disease

  • Autoimmune gluten reaction causing villous atrophy
  • Symptoms: malabsorption, diarrhea, bloating, fatigue
  • PT: monitor for malnutrition, osteoporosis, neuro symptoms (tingling/numbness)

Hepatitis (A-E)

  • Viral liver inflammation
  • Symptoms: jaundice, fatigue, dark urine, RUQ pain
  • PT: energy conservation; avoid strenuous exercise during active infection

Cirrhosis

  • Chronic liver disease with fibrosis
  • Symptoms: jaundice, ascites, hepatomegaly, hepatic encephalopathy
  • PT: watch for bruising/bleeding, fall risk from balance deficits

Pancreatitis

  • Pancreatic inflammation (gallstones, alcohol)
  • Symptoms: severe epigastric pain radiating to back, nausea/vomiting
  • PT: monitor for multi-organ failure signs; avoid abdominal pressure activities

When to stop and notify PT

  • New/worsening abdominal pain
  • Signs of GI bleeding (dark/bloody stool, unexplained fatigue, pallor)

Key referred pain sites

  • Peptic ulcers → epigastric, radiates to back
  • Pancreatitis → mid-back, left shoulder
  • Gallbladder → right shoulder, RUQ, worsens after fatty meals
  • Appendicitis → periumbilical → RLQ (McBurney’s point)
  • Liver → RUQ, right shoulder, jaundice
  • Esophagus → mid chest/back; Stomach → epigastric/LUQ/mid-back
  • Small intestine → periumbilical; Large intestine → lower abdomen/sacral
  • Rectum → sacral/perineum

Male reproductive system anatomy

  • Structures: testes, epididymis, vas deferens, seminal vesicles, prostate, urethra, penis
  • Function: sperm and testosterone production
  • Hormonal axis: Hypothalamus (GnRH) → Pituitary (LH, FSH)
    • LH → testosterone production
    • FSH → spermatogenesis

Male reproductive disorders

  • BPH: non-cancerous prostate enlargement; urinary frequency/nocturia/weak stream
  • Prostatitis: prostate inflammation; painful urination, pelvic pain
  • Prostate cancer: often asymptomatic early; later urinary/bone symptoms
  • Erectile dysfunction: vascular, diabetic, or psychological causes
  • Testicular cancer: common ages 15-35; painless lump/swelling

Female reproductive system anatomy

  • Structures: ovaries, fallopian tubes, uterus, cervix, vagina
  • Function: egg production, hormone production, pregnancy support
  • Hormonal axis: GnRH → LH & FSH
    • LH → ovulation, estrogen/progesterone production
    • FSH → follicle growth and egg maturation

Female reproductive disorders

  • PCOS: irregular ovulation, excess androgens, insulin resistance, hirsutism
  • Endometriosis: ectopic endometrial tissue; pelvic pain, dysmenorrhea, infertility
  • Uterine fibroids: benign tumors; heavy bleeding, pelvic pain
  • PID: reproductive organ infection; pelvic pain, fever, discharge
  • Ovarian cancer: vague early symptoms, often detected late
  • Breast cancer: most common in women; lump, nipple changes, skin dimpling

Pregnancy - musculoskeletal changes

  • Increased lumbar lordosis, anterior pelvic tilt → low back pain
  • Relaxin-induced ligamentous laxity → joint instability
  • Pelvic widening → SI joint/pubic symphysis dysfunction
  • Diastasis recti

Pregnancy - cardiovascular/respiratory changes

  • Increased blood volume (40-50%) and heart rate
  • Decreased BP in 1st/2nd trimester; supine hypotensive syndrome risk (IVC compression)
  • Increased oxygen consumption; decreased lung expansion → shortness of breath

Pregnancy - metabolic and other changes

  • Increased caloric needs; gestational diabetes risk
  • Increased urinary frequency; normal weight gain 25-35 lbs
  • Hormonal shifts affect mood/joints/metabolism
  • Risk of De Quervain’s and carpal tunnel syndrome

Safe exercise guidelines for pregnancy

  • Mode: walking, swimming, cycling, low-impact aerobics
  • Intensity: moderate (talk test); duration: 150 min/week
  • Avoid: supine exercise after 20 weeks, overheating, Valsalva, high-impact/contact sports

Contraindications to exercise during pregnancy

  • Absolute: incompetent cervix, placenta previa (>26 wks), preeclampsia, multiple gestation w/ preterm risk, ruptured membranes, persistent bleeding, preterm labor
  • Relative: severe anemia, unevaluated cardiac disease, chronic bronchitis, poorly controlled diabetes/hypertension

Postpartum considerations

  • Pelvic floor dysfunction: Kegels, biofeedback, bladder retraining
  • Postural syndromes from breastfeeding/carrying: upper back strengthening, postural correction
  • Return to exercise: physician clearance (~6 wks vaginal, 8+ wks C-section); progressive impact return

More from Other system

  • Lymphedema
  • Urinary incontinence and renal disorders
  • Endocrine and metabolic systems
  • Cancer and psychological conditions
  • Infectious disease, immune disorders, and hematological disorders