| Receptor
|
Agonist
|
Antagonist
|
| Alpha 1 (dilator pupillae, vascular smooth muscle)
|
Dopamine; Phenylephrine
|
Prazosin; Doxazosin
|
| Alpha 2 (CNS, presynaptic nerve terminals)
|
Clonidine
|
Yohimbine
|
| Beta 1 (heart, CNS)
|
Dopamine; Dobutamine
|
Atenolol; Metoprolol; Propranolol
|
| Beta 2 (islet cells of pancreas, smooth muscle in bronchioles, blood vessels and uterus)
|
Salbutamol; Terbutaline
|
|
| Beta 3
|
Mirabegron
|
|
| Alpha and beta
|
Epinephrine; Norepinephrine (alpha > beta; causes reflex bradycardia)
|
Labetalol
|
| Alpha
|
|
Phentolamine (reversible); Phenoxybenzamine (irreversible)
|
| Beta 1 and beta 2
|
Dopamine; Isoprenaline
|
Propranolol; Oxprenolol
|
| Angiotensin or AT 1 and AT 2
|
Angiotensin
|
Candesartan (most potent blocker of AT1 receptor); Losartan; Telmisartan; Irbesartan; Valsartan
|
| Muscarinic
|
Acetylcholine; Carbachol; Bethanechol
|
Atropine and analogues; Homatropine; Pirenzepine (M1); Trihexyphenidyl; Tricyclic antidepressants; Quinidine; Disopyramide
|
| Nicotinic
|
Acetylcholine; Carbachol
|
Ganglion blockers; Neuromuscular blockers; Aminoglycoside antibiotics; Quinidine
|
| Dopamine
|
Apomorphine; Bromocriptine; Dopamine
|
Butyrophenones, haloperidol; Domperidone (D2); Metoclopramide; Phenothiazines, chlorpromazine
|
| GABA -A
|
Benzodiazepines; GABA
|
Bicuculline
|
| GABA -B
|
GABA
|
Baclofen
|
| Histamine H1
|
Histamine
|
Antihistamines like cetirizine, promethazine
|
| Histamine H2
|
Histamine
|
Cimetidine; Ranitidine; Famotidine
|
| 5 hydroxytryptamine or 5 HT
|
5HT
|
Methysergide; Sumatriptan (5HT 1D); Ondansetron (5HT 3)
|
| Leukotriene or LT
|
Leukotrienes
|
Montelukast; Zafirlukast
|
| Opioid receptors (μ, δ, and κ)
|
Morphine; Endorphins; Enkephalins; Pentazocine (μ); Buprenorphine (κ) (partial agonist); Fentanyl, alfentanil, remifentanil; Oxycodone; Methadone; Codeine; Papaverine
|
Naltrexone (μ, δ, and κ); Methylnaltrexone (δ); Nalorphine (μ); Naloxone (δ and κ); Buprenorphine (κ) (partial agonist)
|
| Vasopressin V1 and V2
|
Vasopressin (ADH)
|
Conivaptan (V1 and V2); Nelivaptan (V1); Tolvaptan (V2)
|
